Small-molecule targeting of translation initiation for cancer therapy

Translation initiation plays a critical role in the regulation of cell growth and tumorigenesis. We report here that inhibiting translation initiation through induction of eIF2α phosphorylation by small-molecular-weight compounds restricts the availability of the eIF2·GTP·Met-tRNA(i) ternary complex...

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Detaylı Bibliyografya
Asıl Yazarlar: Aktas, Bertal H., Qiao, Yuan, Ozdelen, Esra, Schubert, Roland, Sevinc, Sema, Harbinski, Fred, Grubissich, Luciano, Singer, Samuel, Halperin, Jose A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2013
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858549/
https://ncbi.nlm.nih.gov/pubmed/24091475
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