Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F

Deregulation of cap-dependent translation is associated with cancer initiation and progression. The rate-limiting step of protein synthesis is the loading of ribosomes onto mRNA templates stimulated by the heterotrimeric complex, eukaryotic initiation factor (eIF)4F. This step represents an attracti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cencic, Regina, Hall, David R., Robert, Francis, Du, Yuhong, Min, Jaeki, Li, Lian, Qui, Min, Lewis, Iestyn, Kurtkaya, Serdar, Dingledine, Ray, Fu, Haian, Kozakov, Dima, Vajda, Sandor, Pelletier, Jerry
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2011
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024666/
https://ncbi.nlm.nih.gov/pubmed/21191102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011477108
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