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Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F
Deregulation of cap-dependent translation is associated with cancer initiation and progression. The rate-limiting step of protein synthesis is the loading of ribosomes onto mRNA templates stimulated by the heterotrimeric complex, eukaryotic initiation factor (eIF)4F. This step represents an attracti...
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| Main Authors: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024666/ https://ncbi.nlm.nih.gov/pubmed/21191102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011477108 |
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