Bone Marrow Stromal Cells Derived MCP-1 Reverses the Inhibitory Effects of Multiple Myeloma Cells on Osteoclastogenesis by Upregulating the RANK Expression

Multiple myeloma (MM) cells are responsible for aberrant osteoclast (OC) activation. However, when cocultured monocytes, but not OC precursors, with MM cells, we made a novel observation that MM cells inhibited receptor activator of nuclear factor κB ligand (RANKL)-induced increase of OC differentia...

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Bibliographic Details
Main Authors: Liu, Zhiqiang, Xu, Jingda, Li, Haiyan, Zheng, Yuhuan, He, Jin, Liu, Huan, Zhong, Yuping, Lu, Yong, Hong, Bangxing, Zhang, Mingjun, Lin, Pei, Du, Juan, Hou, Jian, Qian, Jianfei, Kwak, Larry W., Yi, Qing, Yang, Jing
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858321/
https://ncbi.nlm.nih.gov/pubmed/24340030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082453
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