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Germline and somatic KLLN alterations in breast cancer dysregulate G2 arrest
PTEN is a well-described predisposition gene for Cowden syndrome (CS), a familial cancer syndrome characterized by a high risk of breast and other cancers. KLLN, which shares a bidirectional promoter with PTEN, causes cell cycle arrest and apoptosis. We previously identified germline hypermethylatio...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3858115/ https://ncbi.nlm.nih.gov/pubmed/23446638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt097 |
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