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KLLN epigenotype–phenotype associations in Cowden syndrome

Germline KLLN promoter hypermethylation was recently identified as a potential genetic etiology of the cancer predisposition syndrome, Cowden syndrome (CS), when no causal PTEN gene mutation was found. We screened for KLLN promoter methylation in a large prospective series of CS patients and determi...

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Detalhes bibliográficos
Publicado no:Eur J Hum Genet
Main Authors: Nizialek, Emily A, Mester, Jessica L, Dhiman, Vineet K, Smiraglia, Dominic J, Eng, Charis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613489/
https://ncbi.nlm.nih.gov/pubmed/25669429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2015.8
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