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Germline and somatic KLLN alterations in breast cancer dysregulate G2 arrest

PTEN is a well-described predisposition gene for Cowden syndrome (CS), a familial cancer syndrome characterized by a high risk of breast and other cancers. KLLN, which shares a bidirectional promoter with PTEN, causes cell cycle arrest and apoptosis. We previously identified germline hypermethylatio...

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Hlavní autoři: Nizialek, Emily A., Peterson, Charissa, Mester, Jessica L., Downes-Kelly, Erinn, Eng, Charis
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858115/
https://ncbi.nlm.nih.gov/pubmed/23446638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt097
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