Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity

Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of 25% of clinically used drugs. Genetic polymorphisms cause substantial variation in CYP2D6 activity and serve as biomarkers guiding drug therapy. However, genotype–phenotype relationships remain ambiguous except for poor metabolizers carry...

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Autors principals: Wang, Danxin, Poi, Ming J., Sun, Xiaochun, Gaedigk, Andrea, Leeder, J. Steven, Sadee, Wolfgang
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Association Studies Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857955/
https://ncbi.nlm.nih.gov/pubmed/23985325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt417
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