Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity

Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of 25% of clinically used drugs. Genetic polymorphisms cause substantial variation in CYP2D6 activity and serve as biomarkers guiding drug therapy. However, genotype–phenotype relationships remain ambiguous except for poor metabolizers carry...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, Danxin, Poi, Ming J., Sun, Xiaochun, Gaedigk, Andrea, Leeder, J. Steven, Sadee, Wolfgang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2014
Pynciau:
Association Studies Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857955/
https://ncbi.nlm.nih.gov/pubmed/23985325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt417
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