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Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility

The X-linked RHOX cluster encodes a set of homeobox genes that are selectively expressed in the reproductive tract. Members of the RHOX cluster regulate target genes important for spermatogenesis promote male fertility in mice. Studies show that demethylating agents strongly upregulate the expressio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Richardson, Marcy E., Bleiziffer, Andreas, Tüttelmann, Frank, Gromoll, Jörg, Wilkinson, Miles F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857941/
https://ncbi.nlm.nih.gov/pubmed/23943794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt392
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