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Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility

The X-linked RHOX cluster encodes a set of homeobox genes that are selectively expressed in the reproductive tract. Members of the RHOX cluster regulate target genes important for spermatogenesis promote male fertility in mice. Studies show that demethylating agents strongly upregulate the expressio...

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Détails bibliographiques
Auteurs principaux: Richardson, Marcy E., Bleiziffer, Andreas, Tüttelmann, Frank, Gromoll, Jörg, Wilkinson, Miles F.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857941/
https://ncbi.nlm.nih.gov/pubmed/23943794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt392
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