Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions

MutY homologue (MYH) is a DNA glycosylase which excises adenine paired with the oxidative lesion 7,8-dihydro-8-oxoguanine (8-oxoG, or G°) during base excision repair (BER). Base excision by MYH results in an apurinic/apyrimidinic (AP) site in the DNA where the DNA sugar-phosphate backbone remains in...

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Main Authors: Luncsford, Paz J., Manvilla, Brittney A., Patterson, Dimeka N., Malik, Shuja S., Jin, Jin, Hwang, Bor-Jang, Gunther, Randall, Kalvakolanu, Snigdha, Lipinski, Leonora J., Yuan, Weirong, Lu, Wuyuan, Drohat, Alexander C., Lu-Chang, A-Lien, Toth, Eric A.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857741/
https://ncbi.nlm.nih.gov/pubmed/24209961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.09.007
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