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Regression of Lung Cancer by Hypoxia Sensitizing Ruthenium Polypyridyl Complexes
The ruthenium (II) polypyridyl complexes (RPCs) Δ-[(phen)(2)Ru(tatpp)]Cl(2) (Δ-[3]Cl(2)) and ΔΔ-[(phen)(2)Ru(tatpp)Ru(phen)(2)]Cl(4) (ΔΔ-[4]Cl(4)) are a new generation of metal-based anti-tumor agents. These RPCs bind DNA via intercalation of the tatpp ligand which itself is redox-active and easily...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3856889/ https://ncbi.nlm.nih.gov/pubmed/23443803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1130 |
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