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Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose
In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via ultrasmall polymeric nanoparticles (NPs), which rapidly drain to the LN after intradermal injection, greatly enhances adjuvan...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3856841/ https://ncbi.nlm.nih.gov/pubmed/24248387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313152110 |
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