Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via ultrasmall polymeric nanoparticles (NPs), which rapidly drain to the LN after intradermal injection, greatly enhances adjuvan...

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Autori principali: de Titta, Alexandre, Ballester, Marie, Julier, Ziad, Nembrini, Chiara, Jeanbart, Laura, van der Vlies, André J., Swartz, Melody A., Hubbell, Jeffrey A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856841/
https://ncbi.nlm.nih.gov/pubmed/24248387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313152110
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