Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms

Inhibitors of cyclic nucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-term use increases mortality in patients with heart failure. Two isoforms in cardiac myocytes, PDE3A1 and PDE3A2, have identical amino acid sequences except for a unique N-termina...

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Bibliographische Detailangaben
Hauptverfasser: Vandeput, Fabrice, Szabo-Fresnais, Nicolas, Ahmad, Faiyaz, Kho, Changwon, Lee, Ahyoung, Krall, Judith, Dunlop, Allan, Hazel, Mark W., Wohlschlegel, James A., Hajjar, Roger J., Houslay, Miles D., Manganiello, Vincent C., Movsesian, Matthew A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856833/
https://ncbi.nlm.nih.gov/pubmed/24248367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305427110
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