Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation

Lipid transfer proteins, such as molecules of the saposin family, facilitate extraction of lipids from biological membranes for their loading onto CD1d molecules. Although it has been shown that prosaposin-deficient mice fail to positively select invariant natural killer T (iNKT) cells, it remains u...

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Détails bibliographiques
Auteurs principaux: Salio, Mariolina, Ghadbane, Hemza, Dushek, Omer, Shepherd, Dawn, Cypen, Jeremy, Gileadi, Uzi, Aichinger, Michael C., Napolitani, Giorgio, Qi, Xiaoyang, van der Merwe, P. Anton, Wojno, Justyna, Veerapen, Natacha, Cox, Liam R., Besra, Gurdyal S., Yuan, Weiming, Cresswell, Peter, Cerundolo, Vincenzo
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2013
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856826/
https://ncbi.nlm.nih.gov/pubmed/24248359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310050110
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