Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation

Lipid transfer proteins, such as molecules of the saposin family, facilitate extraction of lipids from biological membranes for their loading onto CD1d molecules. Although it has been shown that prosaposin-deficient mice fail to positively select invariant natural killer T (iNKT) cells, it remains u...

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Detalhes bibliográficos
Main Authors: Salio, Mariolina, Ghadbane, Hemza, Dushek, Omer, Shepherd, Dawn, Cypen, Jeremy, Gileadi, Uzi, Aichinger, Michael C., Napolitani, Giorgio, Qi, Xiaoyang, van der Merwe, P. Anton, Wojno, Justyna, Veerapen, Natacha, Cox, Liam R., Besra, Gurdyal S., Yuan, Weiming, Cresswell, Peter, Cerundolo, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856826/
https://ncbi.nlm.nih.gov/pubmed/24248359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310050110
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