Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation

Lipid transfer proteins, such as molecules of the saposin family, facilitate extraction of lipids from biological membranes for their loading onto CD1d molecules. Although it has been shown that prosaposin-deficient mice fail to positively select invariant natural killer T (iNKT) cells, it remains u...

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Autors principals: Salio, Mariolina, Ghadbane, Hemza, Dushek, Omer, Shepherd, Dawn, Cypen, Jeremy, Gileadi, Uzi, Aichinger, Michael C., Napolitani, Giorgio, Qi, Xiaoyang, van der Merwe, P. Anton, Wojno, Justyna, Veerapen, Natacha, Cox, Liam R., Besra, Gurdyal S., Yuan, Weiming, Cresswell, Peter, Cerundolo, Vincenzo
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856826/
https://ncbi.nlm.nih.gov/pubmed/24248359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310050110
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