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Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ(70) domain 1.1

Bacteriophage T7 encodes an essential inhibitor of the Escherichia coli host RNA polymerase (RNAP), the product of gene 2 (Gp2). We determined a series of X-ray crystal structures of E. coli RNAP holoenzyme with or without Gp2. The results define the structure and location of the RNAP σ(70) subunit...

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Main Authors: Bae, Brian, Davis, Elizabeth, Brown, Daniel, Campbell, Elizabeth A., Wigneshweraraj, Sivaramesh, Darst, Seth A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856789/
https://ncbi.nlm.nih.gov/pubmed/24218560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314576110
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