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Secretory protein profiling reveals TNFα inactivation by selective and promiscuous Sec61 modulators
Cotransins are cyclic heptadepsipeptides that bind the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins. The few known cotransin-sensitive substrates are all targeted to the translocon by a cleavable signal sequence, previously shown...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3855466/ https://ncbi.nlm.nih.gov/pubmed/21944747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.06.015 |
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