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Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation

[Image: see text] Photoaffinity labeling is a powerful tool to identify protein targets of biologically active small molecules, yet is often limited by the size, chemical properties, and availability of photo-reactive groups. We report an improved synthesis of photo-leucine, a diazirine-based photo-...

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Detalhes bibliográficos
Main Authors: MacKinnon, Andrew L., Garrison, Jennifer L., Hegde, Ramanujan S., Taunton, Jack
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574519/
https://ncbi.nlm.nih.gov/pubmed/17983236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja076250y
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