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Target Identification by Diazirine Photo-Cross-linking and Click Chemistry
Target identification of biologically active small-molecules is often the rate-determining step in forward chemical genetics. Photo-affinity labeling (PAL) represents a useful biochemical strategy for target identification in complex protein mixtures. This unit describes the use of alkyl diazirine-b...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3647699/ https://ncbi.nlm.nih.gov/pubmed/23667793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/9780470559277.ch090167 |
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