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Substrate-Specific Translocational Attenuation during ER Stress Defines a Pre-Emptive Quality Control Pathway
Eukaryotic proteins entering the secretory pathway are translocated into the ER by signal sequences that vary widely in primary structure. We now provide a functional rationale for this long-observed sequence diversity by demonstrating that differences among signals facilitate substrate-selective mo...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3656606/ https://ncbi.nlm.nih.gov/pubmed/17129784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.10.032 |
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