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Substrate-Specific Translocational Attenuation during ER Stress Defines a Pre-Emptive Quality Control Pathway

Eukaryotic proteins entering the secretory pathway are translocated into the ER by signal sequences that vary widely in primary structure. We now provide a functional rationale for this long-observed sequence diversity by demonstrating that differences among signals facilitate substrate-selective mo...

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Detalhes bibliográficos
Main Authors: Kang, Sang-Wook, Rane, Neena S., Kim, Soo Jung, Garrison, Jennifer L., Taunton, Jack, Hegde, Ramanujan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656606/
https://ncbi.nlm.nih.gov/pubmed/17129784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.10.032
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