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Antigen structure influences helper T-cell epitope dominance in the human immune response to HIV envelope glycoprotein gp120

The development of an effective vaccine against HIV/AIDS has been hampered, in part, by a poor understanding of the rules governing helper T-cell epitope immunodominance. Studies in mice have shown that antigen structure modulates epitope immunodominance by affecting the processing and subsequent pr...

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Autori principali: Mirano-Bascos, Denise, Tary-Lehmann, Magdalena, Landry, Samuel J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855344/
https://ncbi.nlm.nih.gov/pubmed/18398933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200738011
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