Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine

Asparagine synthetase (AS) catalyzes the ATP-dependent conversion of aspartate into asparagine using ammonia or glutamine as nitrogen source. There are two distinct types of AS, asparagine synthetase A (AS-A), known as strictly ammonia-dependent, and asparagine synthetase B (AS-B), which can use eit...

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Autori principali: Loureiro, Inês, Faria, Joana, Clayton, Christine, Ribeiro, Sandra Macedo, Roy, Nilanjan, Santarém, Nuno, Tavares, Joana, Cordeiro-da-Silva, Anabela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854871/
https://ncbi.nlm.nih.gov/pubmed/24340117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002578
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