Building KCNQ1/KCNE1 Channel Models and Probing their Interactions by Molecular-Dynamics Simulations

The slow delayed rectifier (I(Ks)) channel is composed of KCNQ1 (pore-forming) and KCNE1 (auxiliary) subunits, and functions as a repolarization reserve in the human heart. Design of I(Ks)-targeting anti-arrhythmic drugs requires detailed three-dimensional structures of the KCNQ1/KCNE1 complex, a ta...

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Detalhes bibliográficos
Main Authors: Xu, Yu, Wang, Yuhong, Meng, Xuan-Yu, Zhang, Mei, Jiang, Min, Cui, Meng, Tseng, Gea-Ny
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854563/
https://ncbi.nlm.nih.gov/pubmed/24314077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.09.058
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