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Building KCNQ1/KCNE1 Channel Models and Probing their Interactions by Molecular-Dynamics Simulations
The slow delayed rectifier (I(Ks)) channel is composed of KCNQ1 (pore-forming) and KCNE1 (auxiliary) subunits, and functions as a repolarization reserve in the human heart. Design of I(Ks)-targeting anti-arrhythmic drugs requires detailed three-dimensional structures of the KCNQ1/KCNE1 complex, a ta...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Biophysical Society
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3854563/ https://ncbi.nlm.nih.gov/pubmed/24314077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.09.058 |
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