Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression

To improve antibody production in Chinese hamster ovary (CHO) cells, the humanized antibody-producing CHO DP-12-SF cell line was transfected with the gene encoding activating transcription factor 4 (ATF4), a central factor in the unfolded protein response. Overexpression of ATF4 significantly enhanc...

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Bibliografske podrobnosti
Main Authors: Haredy, Ahmad M., Nishizawa, Akitoshi, Honda, Kohsuke, Ohya, Tomoshi, Ohtake, Hisao, Omasa, Takeshi
Format: Artigo
Jezik:Inglês
Izdano: Springer Netherlands 2013
Teme:
JAACT Special Issue
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853642/
https://ncbi.nlm.nih.gov/pubmed/24026344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-013-9631-x
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