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Enhanced IgG1 production by overexpression of nuclear factor kappa B inhibitor zeta (NFKBIZ) in Chinese hamster ovary cells

Several engineering strategies have been employed to improve the production of therapeutic recombinant proteins in Chinese hamster ovary (CHO) cell lines. We have focused on unfolded protein response-based engineering and reported that ATF4 overexpression increases protein production. In this study,...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cytotechnology
Main Authors: Onitsuka, Masayoshi, Kinoshita, Yukie, Nishizawa, Akitoshi, Tsutsui, Tomomi, Omasa, Takeshi
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer Netherlands 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851962/
https://ncbi.nlm.nih.gov/pubmed/29188404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-017-0170-8
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