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Improved antibody production in Chinese hamster ovary cells by ATF4 overexpression
To improve antibody production in Chinese hamster ovary (CHO) cells, the humanized antibody-producing CHO DP-12-SF cell line was transfected with the gene encoding activating transcription factor 4 (ATF4), a central factor in the unfolded protein response. Overexpression of ATF4 significantly enhanc...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer Netherlands
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3853642/ https://ncbi.nlm.nih.gov/pubmed/24026344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-013-9631-x |
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