Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.

Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled receptor kinase-5 (GRK5), a serine/threonine kinase most abundantly expressed in the heart compared with other tissues. Animals overexpressing GRK5 showed marked beta-adrenergic receptor desensitization in b...

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Bibliographic Details
Main Authors: Rockman, H A, Choi, D J, Rahman, N U, Akhter, S A, Lefkowitz, R J, Koch, W J
Format: Artigo
Language:Inglês
Published: 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC38536/
https://ncbi.nlm.nih.gov/pubmed/8790438
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