Small-Molecule G Protein–Coupled Receptor Kinase Inhibitors Attenuate G Protein–Coupled Receptor Kinase 2–Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions

Vasoconstrictor-driven G protein–coupled receptor (GPCR)/phospholipase C (PLC) signaling increases intracellular Ca(2+) concentration to mediate arterial contraction. To counteract vasoconstrictor-induced contraction, GPCR/PLC signaling can be desensitized by G protein–coupled receptor kinases (GRKs...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Rainbow, Richard D., Brennan, Sean, Jackson, Robert, Beech, Alison J., Bengreed, Amal, Waldschmidt, Helen V., Tesmer, John J. G., Challiss, R. A. John, Willets, Jonathon M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086822/
https://ncbi.nlm.nih.gov/pubmed/29980659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112524
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