Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.

Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled receptor kinase-5 (GRK5), a serine/threonine kinase most abundantly expressed in the heart compared with other tissues. Animals overexpressing GRK5 showed marked beta-adrenergic receptor desensitization in b...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rockman, H A, Choi, D J, Rahman, N U, Akhter, S A, Lefkowitz, R J, Koch, W J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38536/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8790438/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.18.9954
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