Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

BACKGROUND: 5-fluorouracil (5-FU) and cisplatin (CDDP) are used to enhance radiotherapy (RT) effect for head and neck (HN) cancers. However, the effect of local RT on systemic chemotherapeutics remains unclear. Here, we evaluated the influence of HN irradiation on the pharmacokinetics (PK) of 5-FU a...

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Hlavní autoři: Hsieh, Chen-Hsi, Hou, Mei-Ling, Chiang, Meng-Hsuan, Tai, Hung-Chi, Tien, Hui-Ju, Wang, Li-Ying, Tsai, Tung-Hu, Chen, Yu-Jen
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853440/
https://ncbi.nlm.nih.gov/pubmed/24066670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-231
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