Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

BACKGROUND: 5-fluorouracil (5-FU) and cisplatin (CDDP) are used to enhance radiotherapy (RT) effect for head and neck (HN) cancers. However, the effect of local RT on systemic chemotherapeutics remains unclear. Here, we evaluated the influence of HN irradiation on the pharmacokinetics (PK) of 5-FU a...

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Main Authors: Hsieh, Chen-Hsi, Hou, Mei-Ling, Chiang, Meng-Hsuan, Tai, Hung-Chi, Tien, Hui-Ju, Wang, Li-Ying, Tsai, Tung-Hu, Chen, Yu-Jen
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853440/
https://ncbi.nlm.nih.gov/pubmed/24066670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-231
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