Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

BACKGROUND: 5-fluorouracil (5-FU) and cisplatin (CDDP) are used to enhance radiotherapy (RT) effect for head and neck (HN) cancers. However, the effect of local RT on systemic chemotherapeutics remains unclear. Here, we evaluated the influence of HN irradiation on the pharmacokinetics (PK) of 5-FU a...

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Bibliografski detalji
Glavni autori: Hsieh, Chen-Hsi, Hou, Mei-Ling, Chiang, Meng-Hsuan, Tai, Hung-Chi, Tien, Hui-Ju, Wang, Li-Ying, Tsai, Tung-Hu, Chen, Yu-Jen
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853440/
https://ncbi.nlm.nih.gov/pubmed/24066670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-231
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