Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin

BACKGROUND: 5-fluorouracil (5-FU) and cisplatin (CDDP) are used to enhance radiotherapy (RT) effect for head and neck (HN) cancers. However, the effect of local RT on systemic chemotherapeutics remains unclear. Here, we evaluated the influence of HN irradiation on the pharmacokinetics (PK) of 5-FU a...

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Autori principali: Hsieh, Chen-Hsi, Hou, Mei-Ling, Chiang, Meng-Hsuan, Tai, Hung-Chi, Tien, Hui-Ju, Wang, Li-Ying, Tsai, Tung-Hu, Chen, Yu-Jen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853440/
https://ncbi.nlm.nih.gov/pubmed/24066670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-231
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