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DNA Double Strand Cleavage via Interstrand Hydrogen Atom Abstraction
Double strand breaks (DSBs) are the most deleterious form of DNA damage. Natural products that produce them are potent cytotoxic agents. Designing molecules that produce DSBs via a single chemical event is challenging. We determined that formation of a C4′-nucleotide radical in duplex DNA under aero...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3852885/ https://ncbi.nlm.nih.gov/pubmed/24147577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja409513q |
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