DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases

[Image: see text] C1027 is a potent antitumor agent that damages DNA. It has the unusual ability to produce double strand breaks and interstrand cross-links (ICLs) intracellularly, which enable it to initiate concurrent ataxia-telangiestasia mutated (ATM) and Rad-3 related (ATR) independent damage r...

Full description

Saved in:
Bibliographic Details
Main Authors: San Pedro, Joanna Maria N., Beerman, Terry A., Greenberg, Marc M.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406177/
https://ncbi.nlm.nih.gov/pubmed/22748380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.06.004
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items