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DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases
[Image: see text] C1027 is a potent antitumor agent that damages DNA. It has the unusual ability to produce double strand breaks and interstrand cross-links (ICLs) intracellularly, which enable it to initiate concurrent ataxia-telangiestasia mutated (ATM) and Rad-3 related (ATR) independent damage r...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406177/ https://ncbi.nlm.nih.gov/pubmed/22748380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.06.004 |
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