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Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg(2+) cofactor
Apurinic/apyrimidinic endonuclease 1 (APE1) mediates the repair of abasic sites and other DNA lesions and is essential for base-excision repair and strand-break repair pathways. APE1 hydrolyzes the phosphodiester bond at abasic sites, producing 5′-deoxyribose phosphate and the 3′-OH primer needed fo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3852660/ https://ncbi.nlm.nih.gov/pubmed/24311596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444913027042 |
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