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Roles of Chk1 in Cell Biology and Cancer Therapy
The evolutionally conserved DNA damage response (DDR) and cell cycle checkpoints preserve genome integrity. Central to these genome surveillance pathways is a protein kinase, Chk1. DNA damage induces activation of Chk1, which then transduces the checkpoint signal and facilitates cell cycle arrest an...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3852170/ https://ncbi.nlm.nih.gov/pubmed/23613359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.28226 |
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