CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells

OBJECTIVE: Overexpression of checkpoint kinase 1 (CHK1) is associated with poorer patient outcome and therapeutic resistance in multiple tumor models. Inhibition of CHK1 has been proposed as a strategy to increase the effectiveness of chemotherapeutic agents, especially in p53-deficient tumors. In t...

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Bibliografiset tiedot
Päätekijät: Grabauskiene, Svetlana, Bergeron, Edward J., Chen, Guoan, Chang, Andrew C., Lin, Jules, Thomas, Dafydd G., Giordano, Thomas J., Beer, David G., Morgan, Meredith A., Reddy, Rishindra M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073640/
https://ncbi.nlm.nih.gov/pubmed/24113549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2013.09.010
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