CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells

OBJECTIVE: Overexpression of checkpoint kinase 1 (CHK1) is associated with poorer patient outcome and therapeutic resistance in multiple tumor models. Inhibition of CHK1 has been proposed as a strategy to increase the effectiveness of chemotherapeutic agents, especially in p53-deficient tumors. In t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Grabauskiene, Svetlana, Bergeron, Edward J., Chen, Guoan, Chang, Andrew C., Lin, Jules, Thomas, Dafydd G., Giordano, Thomas J., Beer, David G., Morgan, Meredith A., Reddy, Rishindra M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073640/
https://ncbi.nlm.nih.gov/pubmed/24113549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2013.09.010
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados