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Akt isoforms differentially protect against stroke-induced neuronal injury by regulating mTOR activities

Protein kinases Akt1 and Akt3 are considered to be more crucial to brain function than Akt2. We investigated the roles of Akt1 and Akt3 in stroke-induced brain injury and examined their interactions with the Akt/mTOR pathways. Focal ischemia was induced in rats. Lentiviral vectors expressing constit...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Xie, Rong, Cheng, Michelle, Li, Mei, Xiong, Xiaoxing, Daadi, Marcel, Sapolsky, Robert M, Zhao, Heng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851893/
https://ncbi.nlm.nih.gov/pubmed/23942361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.132
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