Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment

BACKGROUND: Hunter syndrome (HS) is a lysosomal storage disease caused by iduronate-2-sulfatase (IDS) deficiency and loss of ability to break down and recycle the glycosaminoglycans, heparan and dermatan sulfate, leading to impairment of cellular processes and cell death. Cell activities and functio...

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Main Authors: Mazzoccoli, Gianluigi, Tomanin, Rosella, Mazza, Tommaso, D’Avanzo, Francesca, Salvalaio, Marika, Rigon, Laura, Zanetti, Alessandra, Pazienza, Valerio, Francavilla, Massimo, Giuliani, Francesco, Vinciguerra, Manlio, Scarpa, Maurizio
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851237/
https://ncbi.nlm.nih.gov/pubmed/24083598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-6-37
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