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Conjugation of Butadiene Diepoxide with Glutathione Yields DNA Adducts In Vitro and In Vivo
1,2,3,4-diepoxybutane (DEB) is reported to be the most potent mutagenic metabolite of 1,3-butadiene, an important industrial chemical and environmental pollutant. DEB is capable of inducing the formation of monoalkylated DNA adducts, and DNA-DNA and DNA-protein crosslinks. We previously reported tha...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3850785/ https://ncbi.nlm.nih.gov/pubmed/22181695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200471x |
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