Synchronous BRAF(V600E) and MEK inhibition leads to superior control of murine melanoma by limiting MEK inhibitor induced skin toxicity

The BRAF inhibitor (BRAFi) treatment has led to impressive responses in BRAF(V600E) mutation-positive melanomas, but responses are not durable in many patients. As most of the BRAFi escape mechanisms involve ERK reactivation, combinations with MEK inhibitors (MEKi) are currently tested to improve BR...

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Hlavní autoři: Gadiot, Jules, Hooijkaas, Anna I, Deken, Marcel A, Blank, Christian U
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2013
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849083/
https://ncbi.nlm.nih.gov/pubmed/24348046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S52552
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