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Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats

BACKGROUND: Intracellular calcium (Ca(2+)) coordinates the cardiac contraction cycle and is dysregulated in diabetic cardiomyopathy. Treatment with triethylenetetramine (TETA), a divalent-copper-selective chelator, improves cardiac structure and function in patients and rats with diabetic cardiomyop...

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Bibliografski detalji
Glavni autori: Zhang, Lin, Ward, Marie-Louise, Phillips, Anthony RJ, Zhang, Shaoping, Kennedy, John, Barry, Bernard, Cannell, Mark B, Cooper, Garth JS
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848860/
https://ncbi.nlm.nih.gov/pubmed/23981320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-12-123
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