Copper Chelation by Penicillamine Protects Against Doxorubicin-Induced Cardiomyopathy by Suppressing FDX1-Mediated Cuproptosis

Background: The cardiotoxic effects of doxorubicin (DOX), a powerful chemotherapeutic drug, are widely recognized. Cuproptosis, a unique copper-dependent form of controlled cell death, may be involved in DOX-induced cardiomyopathy, according to recent findings. This study employs both in vivo and in...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Mohammad El-Nablaway, Hany M. A. Sonpol, Yaser Hosny Ali Elewa, Mohamed A. M. Ali, Mohamed Adel, Eman Serry Zayed, Maha Alhelf, Manar A. Didamoony, Amal Fahmy Dawood, Eman M. Embaby, Khaled S. El-Bayoumi, Wesam S. El-Saeed
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-09-01
coleção:	Biomolecules
Assuntos:	pencillamine cuproptosis FDX-1 doxorubicin cardiotoxicity
Acesso em linha:	https://www.mdpi.com/2218-273X/15/9/1320
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!