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ZDHHC13 prevents cuproptosis and enhances radioresistance in nasopharyngeal carcinoma cells by modulating FDX1 protein palmitoylation

Abstract Background Radioresistance is a major obstacle in antitumor therapies. This study explores the effects and functional mechanisms of zDHHC palmitoyltransferase 13 (ZDHHC13) on radioresistance in nasopharyngeal carcinoma (NPC). Methods Bioinformatic and tumor tissue microarray analyses were p...

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Principais autores: Xianjun Lin, Xinrong Hu, Shenhong Qu, Xiaoxue Wang, Haiyun Zhao, Lingping Kong, Jinzhong Huang, Li Zhang, Qing Wen, Xi Lei, Pan Zou
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:European Journal of Medical Research
Fag:
Nasopharyngeal carcinoma
Radioresistance
ZDHHC13
Cuproptosis
FDX1
Palmitoylation
Online adgang:https://doi.org/10.1186/s40001-026-04336-6
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